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Portrait: Leo Wang

Leo Wang

MD, Ph.D
Professional Focus Dr. Leo David Wang is Board certified in pediatrics and pediatric hematology/oncology. Dr. Wang earned his undergraduate degree in molecular biophysics and biochemistry from Yale University, followed by his Ph.D. and medical doctorate at the University of Chicago. He successfully completed an internship and residency in pediatrics at the Children’s Hospital of Philadelphia. Dr. Wang then completed his pediatric hematology/oncology/stem cell transplantation fellowship at the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, and pursued postdoctoral research in the laboratory of Dr. Amy Wagers at the Joslin Diabetes Center and Harvard Stem Cell Institute.
His research focuses on translational science to understand how blood cells develop and grow and use that information to help to treat cancer better. He plans to continue this work on benign and malignant hematopoietic stem cells, as well as to extend his research to investigate critical pathways important in the immune response to cancer. Ultimately, he plans to create a research program that bridges clinical oncology and bone marrow transplantation with fundamental mechanistic research, permitting the translation of novel laboratory findings into clinically important interventions.




Honors & Awards 2017-2019, Hyundai Hope on Wheels Young Investigator Grant
2015-2017, Alex’s Lemonade Stand Foundation Young Investigator Award
2012-2017, St. Baldrick’s Foundation Scholar Award
2012-2016, Damon Runyon-Sohn Foundation Pediatric Cancer Research FellowshipMember - American Society of Blood and Marrow Transplantation
Member - American Society of Clinical Oncology
Member - American Society for Hematology
Member - American Society of Pediatric Hematology and Oncology
Member - International Society of Experimental Hematology
Research & Publications Selected Publications:

HLA Haploidentical Stem Cell Transplant with Pretransplant Immunosuppression for Patients with Sickle Cell Disease.

Pawlowska AB, Cheng JC, Karras NA, Sun W, Wang LD, Bell AD, Gutierrez L, Rosenthal J.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2018; 24(1):185-189.

PubMed [journal]PMID: 28939451
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2.
Phosphoproteomic profiling of mouse primary HSPCs reveals new regulators of HSPC mobilization.

Wang LD, Ficarro SB, Hutchinson JN, Csepanyi-Komi R, Nguyen PT, Wisniewski E, Sullivan J, Hofmann O, Ligeti E, Marto JA, Wagers AJ.

Blood. 2016; 128(11):1465-74.

PubMed [journal]PMID: 27365422 PMCID: PMC5025898
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3.
Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis.

Rowe RG, Wang LD, Coma S, Han A, Mathieu R, Pearson DS, Ross S, Sousa P, Nguyen PT, Rodriguez A, Wagers AJ, Daley GQ.

The Journal of experimental medicine. 2016; 213(8):1497-512.

PubMed [journal]PMID: 27401346 PMCID: PMC4986532
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4.
The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy.

Wang LD, Rao TN, Rowe RG, Nguyen PT, Sullivan JL, Pearson DS, Doulatov S, Wu L, Lindsley RC, Zhu H, DeAngelo DJ, Daley GQ, Wagers AJ.

Leukemia. 2015; 29(6):1320-30. NIHMSID: NIHMS662665

PubMed [journal]PMID: 25655194 PMCID: PMC4456252
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5.
Overlapping roles for endothelial selectins in murine hematopoietic stem/progenitor cell homing to bone marrow.

Nabors LK, Wang LD, Wagers AJ, Kansas GS.

Experimental hematology. 2013; 41(7):588-96. NIHMSID: NIHMS475023

PubMed [journal]PMID: 23499761 PMCID: PMC3700604
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6.
Dynamic niches in the origination and differentiation of haematopoietic stem cells.

Wang LD, Wagers AJ.

Nature reviews. Molecular cell biology. 2011; 12(10):643-55. NIHMSID: NIHMS571834

PubMed [journal]PMID: 21886187 PMCID: PMC4040463
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7.
The pre-B cell receptor in B cell development: recent advances, persistent questions and conserved mechanisms.

Clark MR, Cooper AB, Wang LD, Aifantis I.

Current topics in microbiology and immunology. 2005; 290:87-103.

PubMed [journal]PMID: 16480040
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8.
Selection of B lymphocytes in the periphery is determined by the functional capacity of the B cell antigen receptor.

Wang LD, Lopes J, Cooper AB, Dang-Lawson M, Matsuuchi L, Clark MR.

Proceedings of the National Academy of Sciences of the United States of America. 2004; 101(4):1027-32.

PubMed [journal]PMID: 14722356 PMCID: PMC327145
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9.
B-cell antigen-receptor signalling in lymphocyte development.

Wang LD, Clark MR.

Immunology. 2003; 110(4):411-20.

PubMed [journal]PMID: 14632637 PMCID: PMC1783068
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10.
Igalpha: B all that you can B.

Wang LD, Clark MR.

The Journal of clinical investigation. 1999; 104(8):1011-2.

PubMed [journal]PMID: 10525036 PMCID: PMC408873
11.
Evaluation of the role of cytokine activation in the multiplication of JC virus (JCV) in human fetal glial cells.

Atwood WJ, Wang L, Durham LC, Amemiya K, Traub RG, Major EO.

Journal of neurovirology. 1995; 1(1):40-9.

PubMed [journal]PMID: 9222341
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12.
Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin.

Gelbard HA, Nottet HS, Swindells S, Jett M, Dzenko KA, Genis P, White R, Wang L, Choi YB, Zhang D.

Journal of virology. 1994; 68(7):4628-35.

PubMed [journal]PMID: 8207837 PMCID: PMC236390















Conditions
Neutropenia, Cyclic
Neutropenia
Leukopenia (Neutropenia)
Granulocytopenia (Neutropenia)
Autoimmune Thrombocytopenic Purpura (Idiopathic Thrombocytopenic Purpura (ITP))
stem cell transplant
bone marrow transplant
Severe Combined Immunodeficiency
Common Variable Immunodeficiency
Dyskeratosis Congenita
bone marrow failure
Osteosarcoma (Bone Cancer)
Bone Sarcoma (Bone Cancer)
rhabdomyosarcoma
Osteosarcoma (Bone Cancer)
Ewing Sarcoma (Bone Cancer)
Wilms Tumor
NHL NonHodgkins Lymphomas
Lymphomas NonHodgkins Lymphomas
Lymphoma, Hodgkins (Hodgkins Disease)
Neuroblastoma
Acquired Aplastic Anemia
Beta Thalassemia
Alpha Thalassemia
Hemoglobin H disease (Alpha Thalassemia)
Sickle Cell Disease
Leukemia
Cancer Of The Blood (Leukemia)
Blood Cell Cancer (Leukemia)
Acute Myeloid Leukemia, AML (Leukemia)
Acute Lymphocytic Leukemia (Leukemia)
Procedures
Stem Cell Transplant Peripheral Blood Stem Cell Transplant
Peripheral Blood Stem Cell Transplant
Blood Transfusion
CBC Complete Blood Count
Bone Marrow Transplant Peripheral Blood Stem Cell Transplant
Bone Marrow Biopsy
Dana-Farber/Boston Children’s Cancer
Fellowship
Children’s Hospital of Philadelphia, Pediatrics
Residency
University of Chicago Medicine School, 2005
Medical School
Board Certifications
American Board of Pediatrics
Pediatric Hematology-Oncology
Place of Work
Asst. Professor, Departments of Pediatrics Hematologist/Oncologist , City of Hope National Medical | Hospital Based, Academic | Current
Instructor in Pediatrics, Dana-Farber/Boston Children’s Cancer and Blood Disorders Cen | Hospital Based, Academic | Previous
Languages
French
English