Portrait: Vernon Sutton

Vernon Reid Sutton

MD
Professional Focus Dr. Vernon Sutton is board-certified in Medical Genetics specializing in Clinical Genetics and Clinical Biochemical Genetics. Dr. Sutton's medical interests include skeletal dysplasias, brittle bone disease, achondroplasia, creatine transporter deficiency, Aicardi syndrome, Goltz syndrome, Robinow syndrome, White-Sutton syndrome, and inborn errors of metabolism.

After receiving his undergraduate degree from Transylvania University, Dr. Sutton earned his medical degree from the University of Kentucky College of Medicine. He completed a residency in Pediatrics at Washington University and then a clinical fellowship in Medical Genetics at Baylor College of Medicine.

Currently, Dr. Sutton serves as a Professor of Molecular and Human Genetics and the Vice Chair for Graduate Medical Education in Molecular and Human Genetics at Baylor College of Medicine, the Director of the Inborn Errors of Metabolism Service at Texas Children's Hospital, and the Medical Director of the Biochemical Genetics Laboratory at Baylor Genetics. He also serves as the Director of the Medical Genetics Residency Program for Baylor College of Medicine.

Dr. Sutton's research focuses on osteogenesis imperfecta and skeletal dysplasias. He has contributed to over 200 pieces of medical literature comprised of research publications, books, book chapters, and journal articles. He is the primary investigator of many ongoing clinical trials relating to brittle bone disease as well as other genetic issues. Dr. Sutton has presented both nationally and internationally on topics related to his specialty and is a Fellow of the American College of Medical Genetics and a member of the American Society of Human Genetics, the International Skeletal Dysplasia Society, and the Society of Inherited Metabolic Disease.

Member Feedback:
"Dr. Sutton was very knowledgeable! He was very helpful with answering my specific questions and explaining the details of his answer in an easy-to-digest format. It was nice to know we are doing all we possibly can for our son and a second confirmation was reassuring. He also offered good advice on other topics as we discussed my son's condition."
Honors & Awards Selected Awards:

Master Clinician Lifetime Award, Baylor College of Medicine | 2021

Best Research Mentor, Medical Genetics Residency & Fellowship Programs, Baylor College of Medicine | 2021

Baylor College of Medicine Academy of Distinguished Educators | 2008-2013

Clinical Faculty Teaching Award, Department of Molecular & Human Genetics | 2011

Fulbright & Jaworski, LLP Faculty Excellence Award – Educational Leadership | 2008
Research & Publications Selected Publications [200+]:

Guffon N, Burton BK, Ficicioglu C, Magner M, Gil-Campos M, Lopez-Rodriguez MA, Jayakar P, Lund AM, Tal G, Garcia-Ortiz JE, Stepien KM, Ellaway C, Al-Hertani W, Giugliani R, Cathey SS, Hennermann JB, Lampe C, McNutt M, Lagler FB, Scarpa M, Sutton VR, Muschol N. Monitoring and integrated care coordination of patients with alpha-mannosidosis: A global Delphi consensus study. Mol Genet Metab. 2024 Aug;142(4):108519. doi: 10.1016/j.ymgme.2024.108519. Epub 2024 Jun 23. PMID: 39024860.

Sutton VR, Watt SV, Akhlaghi H, Cipolla DC, Chen KJ, LaSala D, McDonald PP, Beavis PA, Munoz I, Hodel AW, Noori T, Voskoboinik I, Trapani JA. Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells. Front Pharmacol. 2024 Jul 3;15:1396710. doi: 10.3389/fphar.2024.1396710. PMID: 39021839; PMCID: PMC11251990.

Glorieux FH, Langdahl B, Chapurlat R, De Beur SJ, Sutton VR, Poole KES, Dahir KM, Orwoll ES, Willie BM, Mikolajewicz N, Zimmermann E, Hosseinitabatabaei S, Ominsky MS, Saville C, Clancy J, MacKinnon A, Mistry A, Javaid MK. Setrusumab for the treatment of osteogenesis imperfecta: 12-month results from the phase 2b asteroid study. J Bone Miner Res. 2024 Sep 2;39(9):1215-1228. doi: 10.1093/jbmr/zjae112. PMID: 39012717; PMCID: PMC11371902.

Glinton KE, Gijavanekar C, Rajagopal A, Mackay LP, Martin KA, Pearl PL, Gibson KM, Wilson TA, Sutton VR, Elsea SH. Succinic semialdehyde dehydrogenase deficiency: a metabolic and genomic approach to diagnosis. Front Genet. 2024 Jun 19;15:1405468. doi: 10.3389/fgene.2024.1405468. PMID: 39011401; PMCID: PMC11247174.

Chong JX, Berger SI, Baxter S, Smith E, Xiao C, Calame DG, Hawley MH, Rivera-Munoz EA, DiTroia S; Genomics Research to Elucidate the Genetics of Rare Diseases (GREGoR) Consortium; Bamshad MJ, Rehm HL. Considerations for reporting variants in novel candidate genes identified during clinical genomic testing. Genet Med. 2024 Oct;26(10):101199. doi: 10.1016/j.gim.2024.101199. Epub 2024 Jun 26. PMID: 38944749; PMCID: PMC11456385.

Cho HE, Shepherd WS, Colombo GM, Wiese AD, Rork WC, Kostick KM, Nguyen D; Members of the BBDC; Murali CN, Robinson ME, Schneider SC, Qian JH, Lee B, Sutton VR, Storch EA. Resilience and coping: a qualitative analysis of cognitive and behavioral factors in adults with osteogenesis Imperfecta. Disabil Rehabil. 2024 Jun 6:1-10. doi: 10.1080/09638288.2024.2358903. Epub ahead of print. PMID: 38841844.

Shepherd WS, Wiese AD, Cho HE, Rork WC, Baig MU, Kostick KM, Nguyen D, Carter EM; Members of the BBDC; Murali CN, Robinson ME, Schneider SC, Lee B, Sutton VR, Storch EA. Psychosocial Outcomes of Pain and Pain Management in Adults with Osteogenesis Imperfecta: A Qualitative Study. J Clin Psychol Med Settings. 2024 Sep;31(3):614-627. doi: 10.1007/s10880-023-09991-z. Epub 2024 Jan 28. PMID: 38281305; PMCID: PMC11283577.

Rahhal S, Farmer C, Thurm A, Wassif CA, Cawley NX, Perreault J, Dang Do A, Bianconi S, Hannah-Shmouni F, Guthrie W, Cubit LS, Miller JS, Sutton VR, Koeberl D, Porter FD. Corrigendum to "Elevated amyloid beta peptides and total tau in cerebrospinal fluid in individuals with Creatine transporter deficiency". Mol Genet Metab Rep. 2023 Oct 9;37:101013. doi: 10.1016/j.ymgmr.2023.101013. Erratum for: Mol Genet Metab Rep. 2023 Aug 21;37:101001. doi: 10.1016/j.ymgmr.2023.101001. PMID: 38053934; PMCID: PMC10694737.

Jacob P, Lindelöf H, Rustad CF, Sutton VR, Moosa S, Udupa P, Hammarsjö A, Bhavani GS, Batkovskyte D, Tveten K, Dalal A, Horemuzova E, Nordgren A, Tham E, Shah H, Merckoll E, Orellana L, Nishimura G, Girisha KM, Grigelioniene G. Clinical, genetic and structural delineation of RPL13-related spondyloepimetaphyseal dysplasia suggest extra-ribosomal functions of eL13. NPJ Genom Med. 2023 Nov 22;8(1):39. doi: 10.1038/s41525-023-00380-x. PMID: 37993442; PMCID: PMC10665555.

Marom R, Zhang B, Washington ME, Song IW, Burrage LC, Rossi VC, Berrier AS, Lindsey A, Lesinski J, Nonet ML, Chen J, Baldridge D, Silverman GA, Sutton VR, Rosenfeld JA, Tran AA, Hicks MJ, Murdock DR, Dai H, Weis M, Jhangiani SN, Muzny DM, Gibbs RA, Caswell R, Pottinger C, Cilliers D, Stals K; Undiagnosed Diseases Network; Eyre D, Krakow D, Schedl T, Pak SC, Lee BH. Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling. PLoS Genet. 2023 Nov 7;19(11):e1011005. doi: 10.1371/journal.pgen.1011005. PMID: 37934770; PMCID: PMC10656020.
Conditions
Aarskog syndrome
Aase syndrome
Achondroplasia
Achondroplastic dwarfism
Acidemia isovaleric
Acidemia methylmalonic
Acidemia propionic
Acrocallosal syndrome schinzel type
Adams oliver syndrome
Aicardi syndrome
Alpha thalassemia x-linked intellectual disability syndrome
Alport syndrome
Amniotic band syndrome
Angelman syndrome
Angio-osteohypertrophy syndrome
Antley bixler syndrome
Apert syndrome
Arginase deficiency
Argininosuccinic aciduria
Bannayan riley ruvalcaba syndrome
Bardet biedl syndrome
Barth syndrome
Beals syndrome
Beckwith wiedemann syndrome
Blepharophimosis ptosis epicanthus inversus syndrome
Bloom syndrome
Branchio oculo facial syndrome
Branchio oto renal syndrome
C syndrome
Campomelic syndrome
Cardiofaciocutaneous syndrome
Carnitine deficiency syndrome
Carpenter syndrome
Cat eye syndrome
Caudal regression syndrome
Cerebrocostomandibular syndrome
Cerebroside lipidosis syndrome
CHARGE syndrome
Chondromalacia patella
Chromosome 18q- syndrome
Chromosome 22q11.2 deletion syndrome
Citrullinemia type 1
Cobalamin disorders
Cockayne syndrome
Coffin lowry syndrome
Coffin siris syndrome
Cohen syndrome
Conradi hunermann syndrome
Cornelia de Lange syndrome
Costello syndrome
Costochondritis and tietze syndrome
Creatine biosynthesis disorder
Cri du Chat syndrome
Crouzon syndrome
Down syndrome
Dubowitz syndrome
Dyggve melchior clausen syndrome
Dysmetabolic syndrome
Ectodermal dysplasias
Ectrodactyly ectodermal dysplasia cleft lip/palate
Ehlers-Danlos syndrome
Elephantiasis congenita angiomatosa
Ellis van Creveld syndrome
Epidermal nevus syndrome
Familial turner syndrome
Female pseudo-turner syndrome
Fetal alcohol syndrome
FG syndrome type 1
Floating harbor syndrome
Fragile X syndrome
Fraser syndrome
Freeman sheldon syndrome
Gaucher disease
Genetic syndrome
Glycogen storage disease type I
Glycogen storage disease type V
Glycogen storage disease type VII
Greig cephalopolysyndactyly syndrome
Hajdu cheney syndrome
Hallermann streiff syndrome
Hay-wells syndrome
Hemangiectatic hypertrophy
Hermansky pudlak syndrome
Holt oram syndrome
Hunter syndrome
Ichthyosis CHILD syndrome
Ichthyosis netherton syndrome
Inborn errors of metabolism
Jackson-weiss syndrome
Jarcho-levin syndrome
Johanson-blizzard syndrome
Joubert syndrome
Kabuki syndrome
KBG syndrome
Kearns sayre syndrome
Kenny-caffey syndrome
Klinefelter syndrome
Klippel-feil syndrome
Klippel-trenaunay-weber syndrome
Laron syndrome
Larsen syndrome
Lenz microphthalmia syndrome
LEOPARD syndrome
Lesch nyhan syndrome
Loeys-dietz syndrome
Loken senior syndrome
Lowe syndrome
Lymphedema-distichiasis syndrome
Macrocephaly cutis marmorata telangiectatica congenita syndrome
Maffucci syndrome
Male turner syndrome
Malonic acidemia
Marfan syndrome
Maroteaux lamy syndrome
Marshall smith syndrome
Marshall syndrome
Martin-bell syndrome
McCune albright syndrome
Meckel syndrome
MELAS syndrome
Melnick needles syndrome
MERRF syndrome
Metabolic syndrome
Miller syndrome
Mitochondrial encephalomyopathy ( MELAS syndrome )
Moebius syndrome
Morquio syndrome
Mowat-wilson syndrome
Myhre syndrome
Nail patella syndrome
Neu laxova syndrome
Nevoid basal cell carcinoma syndrome
Nonketotic hyperglycinemia
Noonan syndrome
Oculocerebral syndrome with hypopigmentation
Oculocerebrocutaneous syndrome
Oral-Facial-Digital syndrome
Ornithine transcarbamylase deficiency
Orocraniodigital syndrome
Osteogenesis imperfecta
Osteohypertrophic nevus flammeus
Osteopetrosis
Otopalatodigital syndrome type I and II
Pallister hall syndrome
Pallister killian mosaic syndrome
Pallister W syndrome
Partial androgen insensitivity syndrome ( PAIS )
Pendred syndrome
Pfeiffer syndrome
Phelan-McDermid syndrome
Phocomelia syndrome
Poikiloderma atrophicans with cataract
Poikiloderma congenita
Poland syndrome
Prader willi syndrome
Proteus syndrome
Pseudo hurler polydystrophy
Pseudo-Ullrich-Turner syndrome
PTEN hamartoma tumor syndrome
Pterygium syndrome multiple
Rapp hodgkin syndrome
Rett syndrome
Roberts syndrome
Robinow syndrome
Rothmund-thomson syndrome
Rubinstein taybi syndrome
Russell silver syndrome ( RSS )
Ruvalcaba syndrome
Saethre chotzen syndrome
Schinzel giedion syndrome
Schwartz jampel syndrome
Seckel syndrome
SHORT syndrome
Shwachman syndrome
Skeletal dysplasias
Sly syndrome
Smith lemli opitz syndrome
Smith magenis syndrome
Sotos syndrome
Stickler syndrome
Sturge weber syndrome
Stuve-wiedemann syndrome
Three M syndrome
Thrombocytopenia absent radius syndrome
Tietze syndrome
Townes brocks syndrome
Treacher collins syndrome
Tricho dento osseous syndrome
Trichorhinophalangeal syndrome type I
Trichorhinophalangeal syndrome type II
Trichorhinophalangeal syndrome type III
Triplo X syndrome
Triploid syndrome
Trismus pseudocamptodactyly syndrome
Trisomy 13 syndrome
Trisomy 18 syndrome
Trisomy 21
Turner syndrome
Ullrich-noonan syndrome
Urea cycle disorder
Von hippel-lindau syndrome
Waardenburg syndrome
WAGR syndrome/11p deletion syndrome
Walker warburg syndrome
Weaver syndrome
Weill marchesani syndrome
Wiedemann rautenstrauch syndrome
Wildervanck syndrome
Williams syndrome
Winchester syndrome
Wolf hirschhorn syndrome
X-linked opitz G/BBB syndrome
XXY chromosomes
XYY syndrome
Yunis varon syndrome
Procedures
Acylcarnitine profile
Amino acid analysis
Array comparative genomic hybridization
Chromosome analysis
Chromosome microarray analysis
DNA testing
Newborn screening
Organi acid analysis
Whole exome sequencing
Baylor College Of Medicine | Medical Genetics
Fellowship
Washington University School of Medicine | Pediatrics
Internship, Residency
University of Kentucky College of Medicine
Medical School
Board Certifications
American Board of Medical Genetics and Genomics
Clinical Biochemical Genetics
Clinical Genetics and Genomics (MD)
Hospital Affiliation
Texas Children's Hospital
Baylor College of Medicine
Place of Work
Director | Inborn Errors of Metabolism Service | Texas Children's Hospital | Hospital Based | Current
Medical Director | Biochemical Genetics Laboratory | Baylor Genetics | Industry & Research | Current
Professor | Molecular and Human Genetics | Baylor College of Medicine | Academic | Current
Director | Medical Genetics Residency Program | Baylor College of Medicine | Academic | Current
Vice Chair | Graduate Medical Education | Molecular and Human Genetics | Baylor College of Medicine | Academic | Current